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ea0063oc1.3 | Calcium and Bone | ECE2019

Menin and EZH2 activities modulate the expression of the long non-coding RNA HAR1B in parathyroid tumors

Morotti Annamaria , Verdelli Chiara , Guarnieri Vito , Muscarella Lucia Anna , Silipigni Rosa , Guerneri Silvana , Vicentini Leonardo , Vaira Valentina , Corbetta Sabrina

Epigenetic deregulation is emerging as a component of the parathyroid tumorigenesis. We identified a long non-coding RNA (LNCRNA) signature clearly distinguishing parathyroid adenomas (PAds) and carcinomas from normal glands. Among the deregulated LncRNAS, HAR1B was upregulated in PAds harboring the common chromosome 11q loss of heterozygosity (Chr11q-LOH; n=10) compared with PAds harboring normal chromosome 11 haplotype (Chr11q-WT; n=12; P&...

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ea0056oc7.3 | Genomic and clinical aspects of endocrine tumours | ECE2018

LncRNAs profiling reveals epigenetic heterogeneity among human parathyroid tumor

Morotti Annamaria , Verdelli Chiara , Guarnieri Vito , Cetani Filomena , Silipigni Rosa , Guerneri Silvana , Scillitani Alfredo , Vicentini Leonardo , Beretta Edoardo , Vaira Valentina , Corbetta Sabrina

Long noncoding RNAs (LncRNAs) are transcripts of more than 200 nucleotides not translated into proteins. They carry out diverse functions, including transcriptional regulation in cis or trans, organization of nuclear domains, and regulation of proteins or RNA molecules. Aberrant expression of LncRNAs has been reported in human cancers; indeed, data in parathyroid tumors are lacking. Based on the profiling through lncProfilersTM qPCR Array with SYBR...

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Endocrine Abstracts

Menin and EZH2 activities modulate the expression of the long non-coding RNA HAR1B in parathyroid tumors

LncRNAs profiling reveals epigenetic heterogeneity among human parathyroid tumor

BiosciAbstracts